Exercise and Obesity: Activation of Antioxidative Pathway Against Oxidative Stress

Abstract

Obesity is now acknowledged as a primary health burden which impact quality of life heavily due to its various complications. It is a chronic disease of multifactorial origin. Growing evidence proposes that one of the critical factors linking obesity with its associated complications is oxidative stress. Obesity induces systemic oxidative stress which causing the disordered production of adipokines that contributes to the metabolic syndrome development. They are more sensitive towards C-reactive protein (CRP) and other oxidative damage biomarkers. In contrast, the level of antioxidants is glutathione (GSH), which acts against free radicals and reactive oxygen species (ROS) in detoxification of xenobiotic compounds. Moreover, glutathione peroxidase (GPx), one of the most abundant in its family is the most effectual one against oxidant stress in erythrocytes and has some essential functions in phagocytic cells. Besides, it is also in charge of the removal of intracellular hydroperoxides. Therefore, this review attempts to evidence the role of oxidative stress due to obesity as well as antioxidants as the potential opposition to this event as promising interventional theraphy to manage obesity.