The International Journal of Medicine and Sciences - UniSHAMS
http://unisep.lib.unishams.edu.my/xmlui/handle/123456789/11841
Online Journal from Kulliyyah of Medicine & Health Sciences (UniSHAMS)2024-03-29T07:58:06ZThe Use of Multifocal Electroretinogram to Predict Progression of Diabetic Retinopathy
http://unisep.lib.unishams.edu.my/xmlui/handle/123456789/11893
The Use of Multifocal Electroretinogram to Predict Progression of Diabetic Retinopathy
Haizul Ikhwan M., Dr.; Faridah Hanum A., Dr.; Norshamsiah MD., Dr.; Ropilah binti Abdul Rahman, Assoc. Prof. Dr.; Sabrizan O., Dr.; Hazlita I., Dr.
The primary cause of visual loss in diabetic retinopathy (DR) is macular edema. Predicting the occurrence of diabetic macular edema may allow institution of early treatment in diabetic patients. A
prospective observational study was conducted to determine whether abnormal implicit time in multifocal ERG or mfERG (mfERG IT) within the macular region can predict progression of DR after oneyear. A total of fifty patients with type 2 diabetes and mild to moderate non-proliferative diabetic
retinopathy (NPDR) was utilized. At baseline, patients’ mfERG from 61 retinal points within 35 degrees
from the center of fovea were recorded and fundus photographs were taken at baseline and 12 month.
mfERG IT at baseline were measured and fundus photograph were used to monitor progression of DR
within 1-year. The result revealed that 1552 retinal points with abnormal mfERG IT showed DR progression after 1 year. Relative risk of DR progression among retinal points with abnormal mfERG IT
at baseline were 6 times greater than retinal points with normal mfERG IT (RR 6.21; p < 0.001). mfERG
IT at baseline has 89.9% sensitivity and 81.7% specificity to predict progression of DR. In conclusion,
abnormal mfERG IT provides an objective assessment of local retinal health in diabetes and may be
useful to predict DR progression.
2018-06-01T00:00:00ZComparison of Central Corneal Thickness Between Diabetic and Non-Diabetic Population
http://unisep.lib.unishams.edu.my/xmlui/handle/123456789/11892
Comparison of Central Corneal Thickness Between Diabetic and Non-Diabetic Population
KS Wan, Dr.; HF Oh, Dr.; NA Abdul Latiff, Dr.; A Farrah Qistina, Dr.; SL Chieng, Dr.; R Mohd Akmal, Dr.; Aida Zairani MZ, Dr.; Then KY, Dr.
A case control study was conducted to compare the central corneal thickness between diabetic and non-diabetic population. The subjects were 185 Malaysian adults who came to the Universiti Kebangsaan Malaysia Medical Centre (UKMMC) Eye Clinic. The sample was divided into two groups in which there were 90 diabetic and 95 non-diabetic participants. All subjects who fulfilled the inclusion and exclusion criteria were recruited after obtaining informed consents. Central cornea thickness (CCT) measurement was carried out on right eye with a Topcon SP-2000P non-contact specular microscope. Readings would only be taken from the left eye if the right eye did not meet the inclusion criteria. Three measurements were taken and the mean was used as the final result. Over half were Malays (n=103, 55.7%) followed by Chinese (n=69, 37.3%) and Indians (n=13, 7.0%). The mean age for diabetic participants was 59.23±10.02 years, ranging from 38-74 years. Among the non-diabetic participants, the mean age was 57.07±13.68 years, ranging from 23-78 years. The difference between age of diabetics and nondiabetics was not statistically significant (p=0.22). CCT of all participants was normally distributed, with the mean of 526.55± 31.82 μm. The mean CCT in diabetic participants was 531.48± 32.88 μm whereas it was 521.88± 30.22 μm in non-diabetic participants. The increase in CCT found in diabetic participants was statistically significant (p=0.04). This study showed that diabetes is associated with thicker CCT which might contribute to overestimation of intraocular pressure in the management of suspected glaucoma patients.
2018-06-01T00:00:00ZSevere Ocular Neonatal Herpes Simplex Virus Type 2 Infecton : A Case Report
http://unisep.lib.unishams.edu.my/xmlui/handle/123456789/11891
Severe Ocular Neonatal Herpes Simplex Virus Type 2 Infecton : A Case Report
Muhammad Najmi K., Dr.; Aida Zairani MZ., Dr.; Norshamsiah MD., Dr.; Ropilah binti Abdul Rahman, Assoc. Prof. Dr.
We reported a case of a 42 days old baby girl who was diagnosed with bilateral acute retinal necrosis with tractional retinal detachment. She was earlier diagnosed to have disseminated Herpes Simplex Virus (HSV) type 2 infection with encephalitis and treated by the paediatrics team with intravenous aciclovir. She was referred for routine eye assessment and dilated fundus examination revealed extensive peripheral retinal necrosis with some areas of resolving retinitis involving the right macula but sparing the left macula. The ocular disease progressed and tractional retinal detachment developed bilaterally needing vitreoretinal intervention. However, her systemic diseases worsened and she passed away at another tertiary hospital while waiting for the vitreoretinal surgery. This case demonstrates that a patient with such severe retinal necrosis might have normal anterior segment findings. Therefore, it is recommended that all neonates with systemic herpetic infection should be referred ophthalmological assessment early even in the absence of external eye signs as early antiviral treatment can minimise complications of acute retinal necrosis.
2018-06-01T00:00:00ZCase Series of Infectious Retinitis : A 2 Year Review in Hospital Selayang
http://unisep.lib.unishams.edu.my/xmlui/handle/123456789/11890
Case Series of Infectious Retinitis : A 2 Year Review in Hospital Selayang
Mahani M, Dr.; Azian A, Dr.; Amelia LLS, Dr.; Hanizasurana H, Dr.
In Malaysia and globally, infectious diseases remain a complicated and never- ending series of problems affecting multiorgan and system including the eyes. Retinitis as a consequence of infection is potentially sight threatening and occurs in both immunocompetent and immunocompromised individuals. Retinitis may affect human in eye per se or often as a manifestation of systemic illness. A total of 24 patients and 31 eyes were included in this retrospective electronic observational case series review. Only cases with positive history and clinical findings together with positive laboratory findings in Hospital Selayang from
2015 until 2017 were analysed. We excluded Retroviral cases as they may have multifactorial cause of immunodeficiency as a result of opportunistic infections. Our target is to identify common cause of infectious retinitis in immunocompetent and immunocompromised patients hence can offer good treatment and prevent blindness. In the future we plan to extend period of our study to include more cases of infectious retinitis besides to compare differences between those groups.
2018-06-01T00:00:00Z